{"ATC Code":["QV - Various","QV03 - All other therapeutic products","QV03A - All other therapeutic products","QV03AB - Antidotes","QV03AB22 - Amyl nitrite","V - Various","V03 - All other therapeutic products","V03A - All other therapeutic products","V03AB - Antidotes","V03AB22 - Amyl nitrite"],"Absorption, Distribution and Excretion":"Amyl nitrite vapors are absorbed rapidly through the pulmonary alveoli, manifesting therapeutic effects within one minute after inhalation.","Adverse Effects":"Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect","Aliases":["Isoamyl Nitrite","Isoamyl nitrite","Isopentyl nitrite","3-Methylbutyl nitrite","Vaporole","Amilnitrite","Aspiral","Nitrous acid, 3-methylbutyl ester","3-Methylbutanol nitrite","Pentanoli nitris","Nitrous acid, isopentyl ester","Isopentyl alcohol, nitrite","Amyl nitrosum","NSC-7903","CHEBI:2691","Dtxcid402605","Nitrite, Amyl","Nitrous acid, 3-methyl butyl ester","203-770-8","1-Pentyl nitrite","22T8Z09XAK","Amyl Nitrite","Nitramyl","Nitrous Acid, 2-methylbutyl Ester, mixt. with 3-methylbutylnitrite","Amyl nitrite I","Isoamylnitrite","iso-amylnitrite","iso-amyl nitrite","NSC 7903","Mfcd00002057","NCI-C50179","Ncgc00091066-01","Amyl nitrit","Cas-110-46-3","CCRIS 1098","HSDB 606","Einecs 203-770-8","Brn 0969510","isopentylnitrit","Amylnitrit","isoamyInitrite","isopentylnitrite","AI3-25183","Nitrous acid 3-methylbutyl ester","Isoamyl nitrite 97%, stabilized","Vaporole amyl nitrite","Nitrite Isopentyl alcohol","Isopentyl nitrite, 96%","WLN: ONO2Y","3-methyl-1-nitrosooxybutane","isopentyl ester Nitrous acid","Schembl23785","3-methyl-1-nitrosooxy-butane","Chembl1535371","NSC7903","Tox21_111074","Tox21_200983","MSK001918","Akos009157290","Isopentyl nitrite, \u003e=97.0%","Ncgc00091066-02","Ncgc00258536-01","FI106434","LS-13086","DB-002757","I0089","NS00005900","En300-35960","C07457","D00517","F046832","Sr-01000944365","Sr-01000944365-1","F0001-0219","Isoamyl nitrite stab. with 0.2% anhyd. sodium carbonate","Isoamyl nitrite, stab. with 0.2% anhyd. sodium carbonate","InChI=1/C5H11NO2/c1-5(2)3-4-8-6-7/h5H,3-4H2,1-2H"],"Boiling Point":"205 to 210 °F at 760 mmHg (NTP, 1992)","CAS":"110-46-3","Chemical Classes":"Nitrogen Compounds -\u003e Nitrates and Nitrites","ChemicalClasses":[],"Chirality":"achiral","Color/Form":"Yellowish, transparent liquid","DTXSID":"9025455","Density":"0.8528 at 68 °F (NTP, 1992) - Less dense than water; will float g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Indication":"For the rapid relief of angina pectoris.","Drug Warnings":"The nitrates and nitrites should be used with caution, if at all, in patients with increased intracranial pressure (e.g., head trauma, cerebral hemorrhage) and are contraindicated in patients with severe anemia or with a previous idiosyncratic or hypersensitivity reaction to these drugs. /Nitrates and nitrites/","Druglikeness":{"Lipinski":{"Passes":true,"Violations":0}},"Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"203-770-8","Flash Point":"less than 69 °F (NTP, 1992)","Formating":[],"HMDB ID":"HMDB0001382","HeavyAtomCount":8,"IUPACName":"3-methylbutyl nitrite","InChI":"InChI=1S/C5H11NO2/c1-5(2)3-4-8-6-7/h5H,3-4H2,1-2H3","InChIKey":"OWFXIOWLTKNBAP-UHFFFAOYSA-N","Interactions":"...Its effect can be antagonized by any drug that can activate smooth muscle under consideration. Thus, nitrite is functional antagonist of norepinephrine, acetylcholine, histamine... /nitrite/","MeSH Headers":[{"Id":"M0001045","Link":"https://id.nlm.nih.gov/mesh/M0001045.html","Name":"Amyl Nitrite","Ref":74},{"Id":"M0140593","Link":"https://id.nlm.nih.gov/mesh/M0140593.html","Name":"isoamyl nitrite","Ref":76},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":77},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":102},{"Id":"M0022559","Link":"https://id.nlm.nih.gov/mesh/M0022559.html","Name":"Vasodilator Agents","Ref":103}],"MeSH Pharmacological Classification":[{"Id":"M0022559","Link":"https://id.nlm.nih.gov/mesh/M0022559.html","Name":"Vasodilator Agent","Ref":103}],"Mechanism of Action":"Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. Amyl nitrite is a source of nitric oxide, which accounts for the mechanism described above. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin.","Metabolism/Metabolites":"Hepatic. The drug is metabolized rapidly, probably by hydrolytic denitration; approximately one-third of the inhaled amyl nitrite is excreted in the urine.","MolecularFormula":"C\u003csub\u003e5\u003c/sub\u003eH\u003csub\u003e11\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"117.15 g/mol","Odor":"Penetrating fragrant, somewhat fruity odor","Passes":true,"Pharmacodynamics":"Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Adverse effects are related to this pharmacological activity and include hypotension, headache, flushing of the face, tachycardia, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter.","Physical Description":"Isoamyl nitrite is a clear yellow liquid. (NTP, 1992)","PubChemId":8053,"PubChemTitle":"Isoamyl Nitrite","RefChem":"54193","RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Amyl_nitrite","Name":"Amyl nitrite","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q27888090","Name":"Amyl nitrite","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01612","Name":"Amyl nitrite","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/8053","Name":"Amyl nitrite","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=110-46-3","Name":"Amyl nitrite","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0001382","Name":"Amyl nitrite","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07457","Name":"Amyl nitrite","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/5N0U5TUC9Z","Name":"Amyl nitrite","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025455","Name":"Amyl nitrite","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 8053, Amyl nitrite. Accessed June 30, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/8053\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/8053\u003c/a\u003e"],"SMILES":"CC(C)CCON=O","SaltData":[],"Salts":[],"Solubility":"less than 0.1 mg/mL at 64 °F (NTP, 1992)","Stability/Shelf Life":"Unstable and decomposition on exposure to air and light.","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 83.169 26.973\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".8\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h84v27H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M82.062 23.82 68.864 16.2M68.864 16.2V.96M68.864 16.2l-13.198 7.62M55.666 23.82 42.467 16.2M42.467 16.2l-9.589 5.537M25.661 21.737l-6.311-3.644\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m13.402 19.149-6.311 3.644M12.183 17.037l-6.312 3.644\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m13.402 19.149-3.156 1.822\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m7.091 22.793 3.155-1.822\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m12.183 17.037-3.156 1.822\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m5.871 20.681 3.156-1.822\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath stroke=\"none\" d=\"M29.272 21.775q-.738 0-1.173.554-.428.547-.428 1.494t.428 1.494q.435.548 1.173.548t1.167-.548q.429-.547.429-1.494t-.429-1.494q-.429-.554-1.167-.554m0-.548q1.054 0 1.679.709.631.702.631 1.887 0 1.179-.631 1.887-.625.703-1.679.703-1.053 0-1.685-.703-.631-.702-.631-1.887t.631-1.887q.632-.709 1.685-.709\" class=\"atom\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M14.178 13.7h.911l2.214 4.185V13.7h.661v5h-.911l-2.22-4.185V18.7h-.655z\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M2.876 21.775q-.738 0-1.173.554-.429.547-.429 1.494t.429 1.494q.435.548 1.173.548t1.167-.548q.428-.547.428-1.494t-.428-1.494q-.429-.554-1.167-.554m0-.548q1.053 0 1.679.709.631.702.631 1.887 0 1.179-.631 1.887-.626.703-1.679.703-1.054 0-1.685-.703-.631-.702-.631-1.887t.631-1.887q.631-.709 1.685-.709\" class=\"atom\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m32.878 21.737 4.794-2.769M25.661 21.737l-3.155-1.822\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m19.35 18.093 3.156 1.822\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"Pungent, aromatic taste","Therapeutic Uses":"...In emergency treatment of cyanide poisoning... for this purpose, sodium nitrite is employed iv, but amyl nitrite may be inhaled while solution of sodium nitrite is being prepared.","Title":"Amyl nitrite","Toxicity Data":"LC50 (rat) = 716 ppm/4h","UNII":"5N0U5TUC9Z","Violations":0,"Wikidata":"Q27888090","Wikipedia":"Amyl_nitrite","XLogP":1.7}